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Platelet Rich Plasma (PRP) Injections in Medical Research

There have been numerous research and peer reviewed papers published about platelet rich plasma therapy. Here is a selection of some recently published papers for musculoskeletal medicine. Studies have had varied conclusions from little to no benefit, to reports of good success in pain control and potential healing.

(Disclaimer: This page links to websites outside of nirschl.com. Links may have changed since they were listed)

Musculoskeletal medicine

The American Journal of Sports Medicine Feb. 2016 - Plasma injections provide safe and efficacious treatment for knee osteoarthritis. [View abstract]

Monto RR. Platelet-rich plasma efficacy versus corticosteroid injection treatment for chronic severe plantar fasciitis. Foot Ankle Int. 2014 Apr;35(4):313-8. [View abstract]

Gobbi A, Lad D, Karnatzikos G. The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc. 2014 Apr 20. [View abstract]

Abrams GD, Frank RM, Fortier LA, Cole BJ. Platelet-rich Plasma for Articular Cartilage Repair. Sports Med Arthrosc. 2013 Dec;21(4):213-9. doi: 10.1097/JSA.0b013e3182999740. [View abstract]

Filardo G, Kon E, Roffi A, Di Matteo B, Merli ML, Marcacci M. Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration. Knee Surg Sports Traumatol Arthrosc. 2013 Nov 26. [Download full article in PDF format]

Halpern B, Chaudhury S, Rodeo SA, Hayter C, Bogner E, Potter HG, Nguyen J. Clinical and MRI outcomes after platelet-rich plasma treatment for knee osteoarthritis. Clin J Sport Med. 2013 May;23(3):238-9. [View abstract]

Vetrano M, Castorina A, Vulpiani MC, Baldini R, Pavan A, Ferretti A. Platelet-Rich Plasma Versus Focused Shock Waves in the Treatment of Jumper's Knee in Athletes. Am J Sports Med. 2013 Feb 13. [View abstract]

Martinelli N, Marinozzi A, Carnì S, Trovato U, Bianchi A, Denaro V. Platelet-rich plasma injections for chronic plantar fasciitis. Int Orthop. 2012 Dec 19. [View abstract]

Wasterlain AS, Braun HJ, Harris AH, Kim HJ, Dragoo JL. The Systemic Effects of Platelet-Rich Plasma Injection. Am J Sports Med. 2012 Dec 4. [View abstract]

Gobbi A, Karnatzikos G, Mahajan V and Malchira S. Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis Preliminary Results in a Group of Active Patients. Sports Health: A Multidisciplinary Approach 2012 4: 162 [View abstract]

Monto RR. Platelet-Rich Rich Plasma is More Effective than Cortisone for Chronic Severe Plantar Fasciitis. Paper presented at: The American Academy of Orthopaedic Surgeons; 2012 February 7-11; San Francisco, USA. [View abstract]

Sánchez M, Guadilla J, Fiz N, Andia I. Ultrasound-guided platelet-rich plasma injections for the treatment of osteoarthritis of the hip. Rheumatology (Oxford). 2012 Jan;51(1):144-50. Epub 2011 Nov 10. [View abstract]

Filardo G, Kon E, Pereira Ruiz MT, Vaccaro F, Guitaldi R, Di Martino A, Cenacchi A, Fornasari PM, Marcacci M. Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach. Knee Surg Sports Traumatol Arthrosc. 2011 Dec 28. [Epub ahead of print] [View abstract]

Kon E, Mandelbaum B, Buda R, Filardo G, Delcogliano M, Timoncini A, Fornasari PM, Giannini S, Marcacci M. Arthroscopy. Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis. 2011 Nov;27(11):1490-501. Epub 2011 Aug 10. [View abstract]

Filardo G, Kon E, Buda R, Timoncini A, Di Martino A, Cenacchi A, Fornasari PM, Giannini S, Marcacci M. Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2011 Apr;19(4):528-35. Epub 2010 Aug 26. [View abstract]

Gosens T, Peerbooms JC, van Laar W, den Oudsten BL. Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis: A Double-Blind Randomized Controlled Trial With 2-year Follow-up. Am J Sports Med. 2011 Jun;39(6):1200-8. [View abstract]

Wang-Saegusa A, Cugat R, Ares O, Seijas R, Cuscó X, Garcia-Balletbó M. Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life. Arch Orthop Trauma Surg. 2011 Mar;131(3):311-7. Epub 2010 Aug 17. [View abstract]

Kon E, Buda R, Filardo G, Di Martino A, Timoncini A, Cenacchi A, Fornasari PM, Giannini S, Marcacci M. Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):472-9. Epub 2009 Oct 17. [View abstract]

Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T. Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up. Am J Sports Med. 2010 Feb;38(2):255-62. [Download full article in PDF format]

Sampson S, Gerhardt M, Mandelbaum B. Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Curr Rev Musculoskelet Med. 2008 Dec;1(3-4):165-74. [Download full article in PDF format]

Sánchez M, Anitua E, Orive G, Mujika I, Andia I. Platelet-rich therapies in the treatment of orthopaedic sport injuries. Sports Med. 2009;39(5):345-54. [View abstract]

de Vos RJ, Weir A, van Schie HT, Bierma-Zeinstra SM, Verhaar JA, Weinans H, Tol JL. Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. JAMA. 2010 Jan 13;303(2):144-9. [View abstract]

Creaney L, Hamilton B. Growth factor delivery methods in the management of sports injuries: the state of play. Br J Sports Med. 2008 May;42(5):314-20. [View abstract]

Hall MP, Band PA, Meislin RJ, Jazrawi LM, Cardone DA. Platelet-rich plasma: current concepts and application in sports medicine. J Am Acad Orthop Surg. 2009 Oct;17(10):602-8. [View abstract]

Peerbooms, J. C., Sluimer, J., Bruijn, D. J., Gosens, T. Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial: Platelet-Rich Plasma Versus Corticosteroid Injection With a 1-Year Follow-up. Am J Sports Med 38: 255-262 [View abstract]

Mishra A, Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med. 2006 Nov;34(11):1774-8. [View abstract]

Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg. 2004 Nov;114(6):1502-8. [View abstract]

There is ongoing medical research into the use of PRP regarding its potential to heal other musculoskeletal injuries including: trochanteric bursitis, knee MCL tears, knee osteoarthritis and hip osteoarthritis.

Ask your doctor about whether PRP treatment might be an option for your injury.




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